Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Reexamination Certificate
2008-07-08
2008-07-08
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
C424S078190
Reexamination Certificate
active
07396527
ABSTRACT:
Polymers (i.e. polyesters, polyamides, polythioesters, polyanhydrides, or a mixture thereof) which degrade hydrolytically to provide a combination of a beta-lactam antibiotic (e.g., amoxicillin) and a beta-lactamase inhibitor (e.g., clavulanic acid) (or a pharmaceutically acceptable salt thereof) are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver a combination of a beta-lactam antibiotic and a beta-lactamase inhibitor (or a pharmaceutically acceptable salt thereof) to a host are also provided.
REFERENCES:
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Merck Index, 12thed., 1996, pp. 619 and 2404-.
Yagmurlu, et al., “Sulbactam-Cefoperazone Polyhydroxybutyrate-co-Hydroxyvalerate(PHBV) Local Antibiotic Delivery System:In Vivo Effectiveness and Biocompatibity in the Treatment of Implant-Related Experimental Osteomyelitis”,Journal of Biomedical Materials Research,46, Abstract Only, Obtained from Medline, Accession No. 1999326670,(Sep. 15, 1999),494-503.
Leong et al., “Synthesis of Polyanhydrides: Melt-Polycondensation, Dehydrochlorination, and Dehydrative Coupling”,Macromolecules, 20(4), 705-712, (Apr. 1987).
Yu et al., “Poly(N-Acetyl Dopamine Sebacate): A New Polymeric Prodrug of Dopamine”,Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 21, 351-352 (1994).
Hartley Michael G.
Rogers James
Rutgers The State University of New Jersey
Viksnins Harris & Padys PLLP
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