Antibiotic pentalenolactone derivative

Details Antibiotic pentalenolactone derivative Antibiotic pentalenolactone derivative

1978-06-15

1979-04-17

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424279, C07D31194

Patent

active

041500369

ABSTRACT:
Novel antibiotic U-36,699 which has been identified as the .alpha.-methylene derivative of pentalenolactone. Antibiotic U-36,699 has the following structural formula ##STR1## This antibiotic is produced in a chemical process using pentalenolactone (also known as antibiotic P.A. 132), as the starting material. Antibiotic U-36,699 is active against Staphylococus aureua, Sarcina lutea, Mycobacterium phlei, Mycobacterium avium, Saccharomyces cerevisiae, and Penicillium oxalicum. Thus, antibiotic U-36,699 can be used in various environments to eradicate or control such fungi and bacteria. Further, antibiotic U-36,699 inhibits P 388 leukemia cells in laboratory mice. Thus, this antibiotic can be used to treat laboratory mice harboring P 388 leukemia cells.

REFERENCES:
patent: 4083997 (1978-04-01), Houlihan
Chemical Abstracts 8th collective 22540S.
Chemical Abstracts 9th collective 27073CS.

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