Antibiotic nebramycin factor VII

Details Antibiotic nebramycin factor VII Antibiotic nebramycin factor VII

1974-07-31

1976-06-08

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3500

Patent

active

039624277

ABSTRACT:
A process for producing antibiotic nebramycin II, a component antibiotic of the multifactored antibiotic complex nebramycin, and nebramycin VII by culturing Streptomyces tenebrarius NRRL 3816, mutant strain ex Streptomyces tenebrarius ATCC 17920 in an aqueous nutrient culture medium under aerobic fermentation conditions. Nebramycin II is recovered from the filtered fermentation broth by chromatography over a cationic exchange resin and is separated from the newly discovered co-produced minor factor, nebramycin VII, by further chromatography over a cationic exchange resin.

REFERENCES:
patent: 3691279 (1972-09-01), Thompson

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