Antibiotic nanaomycin E and a process for producing the same

Details Antibiotic nanaomycin E and a process for producing the same Antibiotic nanaomycin E and a process for producing the same

1970-11-23

1981-10-20

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424283, 435125, C07D31178

Patent

active

042960401

ABSTRACT:
The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting maerial for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.

REFERENCES:
patent: 3452051 (1969-06-01), Patterson et al.
patent: 3632607 (1972-01-01), Meyer
Ellestad et al., JACS, 90, 1325 (1968).
Omura et al., J. Chem. Soc., Chem. Comm., 9, 320 (1976).
Omura et al., J. Antibiotics, 27, 363 (1974).
Tanaka et al., ibid, 28, 860 (1975).
Tanaka et al., ibid, 28, 868 (1975).
Tanaka et al., ibid, 28, 925 (1975).

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