Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-05-29
1983-03-15
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424251, 424270, 424272, 424273R, 544319, 544320, 544324, 544327, 544330, 546112, 546138, 546183, 546272, 548159, 548181, 548213, 548214, 548222, 548246, 548306, 548318, A61K 3144, C07D40114
Patent
active
043767745
ABSTRACT:
This invention relates to a new class of thienamycins (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics: ##STR1## wherein the stylized radical (hereafter referred to as R'): ##STR2## attached to the amino nitrogen group of thienamycin represents a mono- or polycyclic N-containing heterocyclic group; R is, inter alia, hydrogen, substituted and unsubstituted: alkyl, aryl, alkenyl, heterocyclylalkenyl, aralkenyl, heterocyclylalkyl, aralkyl, --NR.sub.2, COOR, CONR.sub.2, --OR, or CN.
REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4150145 (1979-04-01), Christensen et al.
patent: 4235920 (1980-11-01), Christensen et al.
Brown, A., et al., J.C.S. Chem. Comm., 1977, 523-525.
Doub, L., in Medicinal Chemistry, vol. V, John Wiley and Sons, New York, 1961, pp. 350-353, 362-369 and 410-411.
Northey, E., The Sulfonamides and Related Compounds, Reinhold Pub. Corp., New York, 1948, pp. 377-379.
March, J., Advanced Organic Chemistry, 2nd Ed., McGraw Hill, New York, 1977, p. 598.
Arno J. A.
Mahon F. M.
Merck & Co. , Inc.
Pfeiffer H. J.
Schwartz Richard A.
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