Antibiotic N-acetylbenanomicin B, and the production and uses th

Details Antibiotic N-acetylbenanomicin B, and the production and uses th Antibiotic N-acetylbenanomicin B, and the production and uses th

1989-12-29

1992-03-03

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 33, 514 53, 536 41, 536 64, 536 172, 435238, A61K 3171, A61K 3170, C07H 15252

Patent

active

050933230

ABSTRACT:
As a new compound is now provided N-acetylbenanomicin B which is useful as an antifungal agent and also as antiviral agent for inhibiting infection of human T-cell with HIV, namely a virus causative of acquired human immunodeficiency syndrome. N-acetylbenanomicin B may be prepared by acetylation of 4"-amino group of benanomicin B which is fermentatively produced by a new microorganism, MH193-16F4 strain of actinomycetes.

REFERENCES:
patent: 4973673 (1990-11-01), Sanada et al.
patent: 5055453 (1991-10-01), Takeuchi et al.
T. Oki et al., The Journal of Antibiotics, "Pradimicin, a Novel Class of Potent Antifungal Antibiotics", vol. 41(11) 1988 Nov., pp. 1701-1704.
T. Takeuchi et al., Chemical Abstracts, "New Antifungal Antibiotics, Benanoiciness A and B, from an Actinomycete", vol. 100, No. 15, Oct. 10, 1988, p. 357, col. 1, Abstract-No. 125 508x & J. Antibiotics 41(6):807-811 (1988-Jun.).
The Merck Manual, 15th Edition; pp. 158-168 (1987).
Gomi et al; J. Antibiotics 41(8):1019-1028 (1988-Aug.).

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