Antibiotic from S. clavuligerus

Details Antibiotic from S. clavuligerus Antibiotic from S. clavuligerus

1981-06-09

1985-07-02

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

A61K 3500

Patent

active

045267839

ABSTRACT:
A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.

REFERENCES:
patent: 4144242 (1979-03-01), Fleming et al.
"Pro-Drugs as Novel Drug Delivery Systems", T. Higuchi and V. Stella, Amer. Chem. Soc., Washington, D.C. (1975).

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