Antibiotic derivatives, their production and use

Details Antibiotic derivatives, their production and use Antibiotic derivatives, their production and use

1987-05-21

1990-01-30

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548194, 548243, 548244, C07D41304, C07D41714

Patent

active

048974897

ABSTRACT:
The compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, amino, isonitrile or an organic residue bonded through nitrogen; R.sup.2 is carboxy or a group derivable therefrom; X is hydrogen, methoxy, formylamino, alkyl which may be substituted, alkylthio in which the sulfur atom may be oxidized or azido, or forms a double bond together with the adjacent carbon atom; provided that when R.sup.1 is acetylamino or amino and X is hydrogen, R.sup.2 is not para-nitrobenzyloxycarbonyl or benzhydryloxycarbonyl, or a pharmaceutically acceptable salt thereof, exhibit excellent antimicrobial activity, and are utilized as antimicrobial agents.

REFERENCES:
patent: 4656288 (1987-04-01), Ono
Tetrahedron Letters, 27 (51), 6229-6232, (Dec. 1986).
Nature, 325 (No. 7000), 179-180, (Jan. 8, 1987).

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