Antibiotic derivatives of polyene macrolide group and method of

Details Antibiotic derivatives of polyene macrolide group and method of Antibiotic derivatives of polyene macrolide group and method of

1972-08-10

1978-06-06

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 9, C07H 1708

Patent

active

040937968

ABSTRACT:
A new class of polyene macrolide antibiotics which exhibit valuable therapeutic properties are obtained by reaction of said antibiotics containing at least one amino group with mono- or oligosaccharides, and/or their derivatives in a suitable solvent.
A series of such have been obtained and examined. They all exhibit a high biological activity and form salts which are soluble in water.
Said sugar derivatives of antibiotics can be used as antifungal agents, also as substances to reduce the overgrowth of the prostrate gland and cholesterol level in the blood.

REFERENCES:
patent: 2736725 (1956-02-01), Ritter
patent: 2852429 (1958-09-01), Shepler
patent: 3244590 (1966-04-01), Schaffner et al.
patent: 3541079 (1970-11-01), Schramm et al.

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