Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinoline

Details Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinoline Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinoline

1984-12-06

1986-11-18

Marantz, Sidney

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514236, 546156, 544101, A61K 3147, A61K 31537, C07D21518

Patent

active

046236503

ABSTRACT:
1-Substituted-6-fluoro-7-aryl-(8-fluoro)-1,4-dihydroquinol-4-one 3-carboxylic acids having antibacterial activity are prepared by reacting the corresponding alkyl 1-substituted-6-fluoro-7-bromo-(8-fluoro)-1,4-dihydroquinol-4-one-3-carbox ylate with an arylmetallic compound and hydrolyzing the ester formed.

REFERENCES:
patent: 3472859 (1969-10-01), Lesher
patent: 3907808 (1975-09-01), Lesher
patent: 4398029 (1983-08-01), Irikura
patent: 4443447 (1984-04-01), Gerster
Koga J. Medicinal Chemistry 23, 1358-1363 (1980).

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