Antibiotic derivatives of 7.beta.-[2-(thiazol-4-yl)acetamide]-3-

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540222, A61K 31545, C07D50120

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active

046832270

ABSTRACT:
7.beta.-Heterocyclicacetylamino-(and 7.beta.-heterocyclicthioacetamido)-3-chloro-3-cephem-4-carboxylic acids and pharmaceutically acceptable salts thereof, e.g., 7.beta.-[2-(2-aminothiazol-4-yl)acetamido]-3-chloro-3-cephem-4-carboxylic acid and salts thereof, exhibit surprising peroral bioavailability and are useful in a method for treating infections in man and animals and in formulations for oral administration.

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J. A. Webber et al., in "Structure Activity Relationships Among the Semisynthetic Antibiotics", Academic Press, Inc., N.Y., 1977, pp. 170-182.

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