Antibiotic derivatives of 7.beta.-[2-(thiazol-4-yl)acetamide]-3-

Details Antibiotic derivatives of 7.beta.-[2-(thiazol-4-yl)acetamide]-3- Antibiotic derivatives of 7.beta.-[2-(thiazol-4-yl)acetamide]-3-

1985-07-09

1987-07-28

Warden, Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540222, A61K 31545, C07D50120

Patent

active

046832270

ABSTRACT:
7.beta.-Heterocyclicacetylamino-(and 7.beta.-heterocyclicthioacetamido)-3-chloro-3-cephem-4-carboxylic acids and pharmaceutically acceptable salts thereof, e.g., 7.beta.-[2-(2-aminothiazol-4-yl)acetamido]-3-chloro-3-cephem-4-carboxylic acid and salts thereof, exhibit surprising peroral bioavailability and are useful in a method for treating infections in man and animals and in formulations for oral administration.

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Dunn J. Antimicrobial Chemotherapy (1982) 10, Supple. C pp. 1-10.
J. A. Webber and W. J. Wheeler, "Chemistry and Biology of Beta-Lactam Antibiotics vol. 1, Penicillins and Cephalosporins", R. B. Morin et al., Ed., Academic Press, N.Y, 1982, Chap. 4, pp. 391-397.
J. A. Webber et al., in "Structure Activity Relationships Among the Semisynthetic Antibiotics", Academic Press, Inc., N.Y., 1977, pp. 170-182.

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