Antibiotic derivatives

Details Antibiotic derivatives Antibiotic derivatives

1975-09-11

1978-05-30

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560188, C07C 6966, A61K 31225

Patent

active

040924246

ABSTRACT:
Disclosed is a process for producing the antibiotic pleuromutilin by cultivating strains of Clitopilus passeckerianus (Pil.) Sing in an aqueous nutrient medium. The production of esters of pleuromutilin and hydrogenation products thereof are also described. The pleuromutilin and derivatives thereof are useful as an antibacterial ingredient in animal feed compositions.
The disclosure also describes derivatives of pleuromutilin which are useful in veterinary medicine. These derivatives include esters obtained by reacting pleuromutilin or its hydrogenation products with reactive compounds such as acid halides, acid anhydrides, esters and the like, of isocyanic acid, aliphatic monocarboxylic acids or dicarboxylic acids containing at least 3 carbon atoms or sulfonic acids.

REFERENCES:
anchel, M., J. Biol. Chem., 199, 133-9, (1952).

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