Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1998-03-24
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2104, C07H 2102
Patent
active
057311498
ABSTRACT:
The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence:
REFERENCES:
patent: 4304715 (1981-12-01), Hudson et al.
patent: 4543252 (1985-09-01), Lehrer et al.
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 5032574 (1991-07-01), Wilde et al.
patent: 5191015 (1993-03-01), Sheppard et al.
patent: 5237051 (1993-08-01), Garbers et al.
patent: 5436155 (1995-07-01), Belle et al.
patent: 5438121 (1995-08-01), Barde et al.
Notification of Transmittal of International Search Report for PCT/US95/13328 mailed 21 Feb. 1996.
Selsted, Michael A. "Enteric Defensins: Antibiotic Peptide Components of Intestinal Host Defense." J. Cell. Biol. 118:929-936 (1992).
Maurer, Paul H. and Callahan, Hugh J., "Proteins and Polypeptides as Antigens." Methods in Ezymology 70:49-70 (1980).
Eisenhauer, Patricia B. et al., "Cryptdins: Antimicrobial Defensins of the Murine Small Intestine." Infection and Immunity 60:3556-3565 (1992).
Ouellette, Andre J. et al., "Developmental Regulation of Cryptdin, a Corticostatin/Defensin Precursor mRNA in Mouse Small Intestinal Crypt Epithelium." J. Cell. Biol. 108:1687-1695 (1989).
Ouellette, Andre J. et al., "Purification and Primary Structure of Murine Cryptdin-1, a Paneth Cell Defensin." FEBS 304:146-148 (1992).
Ouellete, Andre J. and Lualdi, John C., "A Novel Mouse Gene Family Coding for Cationic, Cysteine-rich Peptides." J. Biol. Chem. 265:9831-9837 (1990).
Ganz, Tomas et al., "Defensins." Eur. J. Haematol. 44:1-8 (1990).
Kagan, Bruce L. "Antimicrobial Defensin Peptides Form Voltage-Dependent Ion-Permeable Channels in Planar Lipid Bilayer Membranes." Proc. Natl. Acad. Sci. USA 87:210-214 (1990).
Ouellette, Andre J. et al., "Localization of the Cryptdin Locus on Mouse Chromosome 8." Genomics 5;233-239 (1989).
Wimley, William C. et al., "Interactions Between Human Defensins and Lipid Bilayers: Evidence for Formation of Multimeric Pores." Protein Sci. 3:1362-1373 (1994).
Selsted, Michael E., "Investigational Approaches for Studying the Structures and Biological Functions of Myeloid Antimicrobial Peptides." Genetic Eng. 15:131-147 (1993).
Huttner, Kenneth M. et al., "Structure and Diversity of the Murine Cryptdin Gene Family." Genomics 19:448-453 (1994).
Ouellette, Andre J. et al., "Mouse Paneth Cell Defensins: Primary Structures and Antibacterial Activities of Numerous Cryptdin Isoforms." Infect. and Immun. 62:5040-5047 (1994).
Aley, Stephen B. et al., "Killing of Giardia Lamblia by Cryptdins and Cationic Neutrophil Peptides." Infect. and Immun. 62:5397-5403 (1994).
Miller, S.I. et al., "Purification and Characterization of a Secreted Paneth Cell Defensin Using phoP Mutants of Salmonella Typhimurium." ASCB/EMBO Summer Conference. p. 48 (1991) vol. # Not Applicable.
Chow, M.-S. et al., "Fmoc Solid Phase Peptide Synthesis of Defensins." Proceeding of the Sixth Symposium of The Protein Society. p. 135 (1992) vol. # Not Applicable.
Ouellette et al. JBC 265:9831-9837, 1990.
Ouellette et al. JCB 108:1687-1691, 1989.
Traber et al. Am. J. of Physiol. 260:G895-G903, 1991.
Ouellette Andre J.
Selsted Michael E.
Jones W. Gary
Rees Dianne
The Shriner's Hospital for Crippled Children
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