Antibiotic cryptdin peptides and methods of their use

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

5303871, 5303881, 5303879, 5303891, 435 4, 435 72, 435 721, 435 79, 435 791, 435 792, 435 793, 435 794, 435 795, 435 405, 435 4052, 435325, 435326, 435331, 436518, 436161, 436162, G01N 3353, G01N 33542, G01N 33537, G01N 33543

Patent

active

058404988

ABSTRACT:
The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence:

REFERENCES:
patent: 4304715 (1981-12-01), Hudson et al.
patent: 4543252 (1985-09-01), Lehrer et al.
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 5032574 (1991-07-01), Wilde et al.
patent: 5191015 (1993-03-01), Sheppard et al.
patent: 5459235 (1995-10-01), Selsted et al.
Campbell, Monoclonal Antibody Techonology, Elseiver Science Pub. pp. 1-32, 1986.
Panyutoch et al J. Immunological Methods vol. 141 p. 149, Aug. 1991.
Selsted, Michael A. "Enteric Defensins: Antibiotic Peptide Components of Intestinal Host Defense." J. Cell. Biol. 118:929-936 (1992).
Maurer, Paul H. and Callahan, Hugh J., "Proteins and Polypeptides as Antigens." Methods in Ezymology 70:49-70 (1980).
Eisenhauer, Patricia B. et al., "Cryptdins: Antimicrobial Defensins of the Murine Small Intestine." Infection and Immunity 60:3556-3565 (1992).
Ouellette, Andre J. et al., "Developmental Regulation of Cryptdin, a Corticostatin/Defensin Precursor mRNA in Mouse Small Intestinal Crypt Epithelium." J. Cell. Biol. 108:1687-1695 (1989)..
Ouellette, Andre J. et al., "Purification and Primary Structure of Murine Cryptdin-1, a Paneth Cell Defensin." FEBS 304:146-148 (1992).
Ouellette, Andre J. and Lualdi, John C., "A Novel Mouse Gene Family Coding for Cationic, Cysteine-rich Peptides." J. Biol. Chem. 265:9831-9837 (1990).
Ganz, Tomas et al., "Defensins." Eur. J. Haematol. 44:1-8 (1990).
Kagan, Bruce L. "Antimicrobial Defensin Peptides Form Voltage-Dependent Ion-Permeable Channels in Planar Lipid Bilayer Membranes." Proc. Natl. Acad. Sci. USA 87:210-214 (1990).
Ouellette, Andre J. et al., "Localization of the Cryptdin Locus on Mouse Chromosome 8." Genomics 5:233-239 (1989).
Wimley, William C. et al., "Interactions Between Human Defensins and Lipid Bilayers: Evidence for Formation of Multimeric Pores." Protein Sci. 3:1362-1373 (1994).
Selsted, Michael E., "Investigational Approaches for Studying the Structures and Biological Functions of Myeloid Antimicrobial Peptides." Genetic Eng. 15:131-147 (1993).
Huttner, Kenneth M. et al., "Structure and Diversity of the Murine Cryptdin Gene Family." Genomics 19:448-453 (1994).
Ouellette, Andre J. et al., "Mouse Paneth Cell Defensins: Primary Structures and Antibacterial Activities of Numerous Cryptdin Isoforms." Infect. and Immun. 62:5040-5047 (1994).
Aley, Stephen B. et al., "Killing of Giardia Lamblia by Cryptdins and Cationic Neutrophil Peptides." Infect. and Immun. 62:5397-5403 (1994).
Miller, S.I. et al., "Purification and Characterization of a Secreted Paneth Cell Defensin Using phoP Mutants of Salmonella Typhimurium." ASCB/EMBO Summer Conference. (1991). Abstract.
Chow, M.-S. et al., "Fmoc Solid Phase Peptide Synthesis of Defensins." Proceeding of the Sixth Symposium of The Protein Society. (1992). Abstract.
Notification of Transmittal of International Search Report for PCT/US95/13328 mailed 21 Feb. 1996.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antibiotic cryptdin peptides and methods of their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotic cryptdin peptides and methods of their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotic cryptdin peptides and methods of their use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1700610

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.