Antibiotic cryptdin peptides and methods of their use

Details Antibiotic cryptdin peptides and methods of their use Antibiotic cryptdin peptides and methods of their use

1992-08-14

1995-06-06

Saunders, David

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530806, C07K 710

Patent

active

054224241

ABSTRACT:
The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence as follows:

REFERENCES:
patent: 3714140 (1973-01-01), Sipos
patent: 4543252 (1985-09-01), Lehrer et al.
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 5032574 (1991-07-01), Wilde et al.
patent: 5191015 (1993-03-01), Sheppard et al.
Eisenhauer, Patricia B. et al. "Cryptdins: Antimicrobial Defensins of the Murine Small Intestine." Infection and Immunity. 60:3556-3565 (1992).
Ouellette et al, 1989. Developmental regulation of cryptdin, a corticostatin/definsin precursor mRNA in mouse small intestinal crypt epithelium. J. Cell Biol. 108:1687-95.
Ouellette et al, Jun. 1992. Purification and primary structure of murine cryptdin-1, a Paneth cell defensin. FEBS Lett. 304:146-8.
Selsted et al, Aug. 1992. Enteric defensins: antibiogic peptide components of intestinal host defense. J Cell Biol. 118:929-36.
Daher et al, 1988. Isolation and characterization of human defensin cDNA clones. Proc. Natl. Acad Sci. 85:7327-31.
Ganz et al, 1989. The structure of the rabbit macrophage defensin genes and their organ-specific expression. J. Immunol. 143:1358-65.
Ganz et al, 1985. Defensins. Natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76:1427-35.
Maurer et al, 1980. Proteins and polypeptides as antigens. Meth. Enzymol. 70:49-70.
Stewart et al, 1984. Solid Phase Peptide Synthesis. Pierce Chemical Co., Rockford. pp. 90-91.
Ouellette, Andre J. and Lualdi, John C. "A Novel Mouse Gene Family Coding for Cationic, Cysteine-rich Peptides." J. Biol. Chem. 265:9831-9837 (1990).
Ganz, Tomas et al., "Defensins." Eur. J. Haematol. 44:1-8 (1990).
Kagan, Bruce L. "Antimicrobial Defensin Peptides Form Voltage-Dependent Ion-Permeable Channels in Planar Lipid Bilayer Membranes." Proc. Natl. Acad. Sci. USA 87:210-214 (1990).
Ouellette, Andre J. et al., "Localization of the Cryptdin Locus on Mouse Chromosome 8." Genomics 5:233-239 (1989).

Affiliated with

Also associated with

Rating

Antibiotic cryptdin peptides and methods of their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotic cryptdin peptides and methods of their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotic cryptdin peptides and methods of their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-988505