Antibiotic compounds, process for the preparation and pharmaceut

Details Antibiotic compounds, process for the preparation and pharmaceut Antibiotic compounds, process for the preparation and pharmaceut

1984-03-02

1986-05-13

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

260112R, 435884, 514 2, 530300, A61K 3700, C07G 700, C12R 145, C12N 120

Patent

active

045886920

ABSTRACT:
The invention relates to an antibiotic polypeptide compound, or addition salt thereof, having a molecular weight no greater than 10000 and possessing bactericidal and bacteriolytic activities in respect of Gram-positive bacteria, the said compound comprising within the molecular structure thereof amino acid derivative units of formulae --NR--R.sub.1 --CO--, --NH--R.sub.2 --CO--, --NH--R.sub.3 --CO--, --NH--R.sub.4 --CO--, --NH--R.sub.5 --CO--, --NH--R.sub.6 --CO--, --NH--R.sub.7 --CO-- and ##STR1## wherein NH.sub.2 --R.sub.1 --COOH, NH.sub.2 --R.sub.2 --COOH, NH.sub.2 --R.sub.3 --COOH, NH.sub.2 --R.sub.4 --COOH, NH.sub.2 --R.sub.5 --COOH, NH.sub.2 --R.sub.6 --COOH and NH.sub.2 --R.sub.7 --COOH respectively represent isoleucine, phenylalanine, alanine, aspartic acid, glutamic acid, lysine and glycine and ##STR2## represents proline. The invention further provides a process for the preparation of antibiotic polypeptides by the aerobic culturing of a strain of S. epidermidis.
The invention also provides compositions comprising antibiotic substances and methods of treatment therewith.
The invention further provides a new strain of Staphylococcus epidermidis which produces the antibiotic polypeptides, compositions containing the said strain and a method of cosmetic or prophylactic treatment of the human skin with such compositions.

REFERENCES:
Jetten, A., et al., J. Bacteriol., vol. 112, No. 1, pp. 243-250 (1972).

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