Antibiotic compounds

Details Antibiotic compounds Antibiotic compounds

2006-05-09

2006-05-09

Jones, Dwayne (Department: 1614)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S453000, C548S537000, C514S210030, C514S210110, C514S210130, C514S414000, C540S200000, C540S302000, C540S350000

Reexamination Certificate

active

07041836

ABSTRACT:
The present invention relates to carbapenems and provides a compound of the formula (I):or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:R1is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl;R2is hydrogen or C1-4alkyl;R3is hydrogen or C1-4alkyl;R4and R5are the same or different and are selected from hydrogen, halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, C1-4alkoxycarbonyl, aminosulphonyl, C1-4alkylaminosulphonyl, di-C1-4-alkylaminosulphonyl, carbamoyl, C1-4alkylcarbamoyl, di-C1-4-alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C1-4alkylamino, di-C1-4alkylamino, C1-4alkanoylamino, C1-4alkanoyl(N—C1-4alkyl)amino, C1-4alkanesulphonamido and C1-4alkylS(O)n— wherein n is zero, one or two:with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to —NR3—. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

REFERENCES:
patent: 4206219 (1980-06-01), Christensen
patent: 4208422 (1980-06-01), Christensen
patent: 4218462 (1980-08-01), Christensen
patent: 4232036 (1980-11-01), Christensen
patent: 4740507 (1988-04-01), Sugimura
patent: 4746736 (1988-05-01), Kim
patent: 4933333 (1990-06-01), Sunagawa
patent: 4943569 (1990-07-01), Sunagawa
patent: 4962103 (1990-10-01), Sunagawa
patent: 4963544 (1990-10-01), Murata
patent: 4974544 (1990-12-01), Ohta
patent: 5093328 (1992-03-01), Sunagawa
patent: 5102997 (1992-04-01), Sugimura et al.
patent: 5194624 (1993-03-01), Murata
patent: 5215983 (1993-06-01), Murata
patent: 5441949 (1995-08-01), Jung
patent: 5444057 (1995-08-01), Jung
patent: 5447925 (1995-09-01), Betts
patent: 5478820 (1995-12-01), Betts et al.
patent: 5478828 (1995-12-01), Mattson et al.
patent: 5527791 (1996-06-01), Betts
patent: 5527793 (1996-06-01), Junge
patent: 5541178 (1996-07-01), Betts
patent: 5554606 (1996-09-01), Betts
patent: 5571805 (1996-11-01), Jung et al.
patent: 5652233 (1997-07-01), Betts et al.
patent: 5856321 (1999-01-01), Betts et al.
patent: 6187804 (2001-02-01), Betts et al.
patent: 6521612 (2003-02-01), Betts et al.
patent: 0 017 992 (1980-10-01), None
patent: 0 126 587 (1984-11-01), None
patent: 0160 391 (1985-11-01), None
patent: 0 182 213 (1986-05-01), None
patent: 0 243 686 (1987-11-01), None
patent: 0 443 883 (1991-08-01), None
patent: 0 472 062 (1992-02-01), None
patent: 60 233 076 (1985-11-01), None
patent: 9 217 481 (1992-10-01), None
Betts, CA 118(9)=80721d (1992).
Betts, CA 118(7)=59495y (1992).

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