Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-06-07
2001-11-13
Higel, Floyd D. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S537000
Reexamination Certificate
active
06316488
ABSTRACT:
BACKGROUND OF THE INVENTION
The present invention relates to a broad spectrum aralkyl-peptide antibiotic compound that is useful in treating gram negative and gram positive bacterial infections.
Infections caused by gram negative bacteria are a growing medical concern as many of these bacteria are resistant to various gram negative antibiotics, especially antibiotics for treating
Pseudomonas aeruginosa, Vibrio cholerae, Vibrio parahemolyticus, Actinobacter calcoaeticus
and
Stenotrophomonas maltophilia.
In addition, many Gram positive bacteria are resistant to these Gram negative antibiotics, especially
Staphylococcus aureus, Staphylococcus hemolyticus,
Pediococcus spp., and
Streptococcus pyogenes
and
Streptococcus pneumoniae.
The antibiotic of this invention, thus comprises an important contribution to therapy for treating infections which are resistant to various known antibiotics.
A prior art compound that is also an aralkyl-peptide and which is used for treating bacterial infections is Vibriobactin, which has the following structure:
In the present invention, the aralkyl-peptide antibiotic is produced from a eubacterial fermentation and possesses antibacterial activity against gram negative and gram positive bacterial infections many of which have demonstrated resistance to currently available antibiotics.
SUMMARY OF THE INVENTION
This invention is concerned with a novel aralkyl-peptide antibiotic of the formula I:
or a pharmaceutically acceptable salt thereof which is effective in the treatment of gram negative and gram positive bacterial infections.
The invention is also concerned with a process for the production of Compound I by fermentation with a eubacterial Pseudomonas sp.
The invention is also concerned with a process for isolating Compound I from the fermentation broth.
REFERENCES:
patent: 5510369 (1996-04-01), Lumma et al.
patent: 5744487 (1998-04-01), Ohshima et al.
patent: 6239150 (2001-05-01), Oshima et al.
patent: 0 007 614 B1 (1980-02-01), None
patent: 0 072 014 B1 (1983-02-01), None
J. Biol. Chem. 1984, 259(1), 383-385.
Bernard-King Aurora M.
Salvatore, Jr. Michael J.
Tsipouras Athanasios
Wilson Kennth E.
Ayler Sylvia A.
Daniel Mark R.
Higel Floyd D.
Jang Soonhee
Merck & Co. , Inc.
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