Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-01-15
1983-10-11
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
044092105
ABSTRACT:
A novel water-soluble peptide designated herein as Bu-2517 is produced by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962). The antibiotic exists in a cyclic depsipeptide structure and contains the amino acids D-serine, D-proline, L-proline, D-threo-.beta.-hydroxyaspartic acid, L-threo-.beta.-hydroxyaspartic acid, L-arginine and trans-L-3-hydroxyproline and the residue of the C.sub.14 fatty acid, 3-hydroxytetradecanoic acid. The Bu-2517 antibiotic inhibits the growth of a variety of aerobic and anaerobic gram-positive bacteria.
Kawaguchi Hiroshi
Konishi Masataka
Sugawara Koko
Tomita Koji
Bristol-Myers Company
Morse David M.
Phillips Delbert R.
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