Antibiotic bonding of vascular prostheses and other implants

Details Antibiotic bonding of vascular prostheses and other implants Antibiotic bonding of vascular prostheses and other implants

1982-02-22

1984-04-10

Frinks, Ronald L.

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

3 1, 3 14, 128334R, A61F 100, A61F 124

Patent

active

044421338

ABSTRACT:
A method of preparing a surgical vascular graft wherein a length of graft material carries an absorbed coating of tridodecyl methyl ammonium chloride (TDMAC) surfactant and an antibiotic bound thereto. A length of graft material such as polytetrafluoroethylene or Dacron is soaked in a 5% by weight solution of TDMAC for 30 minutes at room temperature, air dried and then washed in distilled water to remove excess TDMAC. The graft carrying the absorbed cationic TDMAC surfactant coating is incubated in a solution of negatively charged antibiotic for one hour, washed in sterile water to remove unbound antibiotic and stored for use in the operating room.

REFERENCES:
patent: 3425418 (1969-02-01), Chvapil et al.
patent: 3520949 (1970-07-01), Shepherd et al.
patent: 4116898 (1978-09-01), Dudley et al.
patent: 4302368 (1981-11-01), Dudley et al.

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