Antibiotic aminoglycosides, processes of preparation and pharmac

Details Antibiotic aminoglycosides, processes of preparation and pharmac Antibiotic aminoglycosides, processes of preparation and pharmac

1975-03-11

1977-12-20

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 4, 536 18, 536 53, 536122, C07H 1522, A61K 3171

Patent

active

040643395

ABSTRACT:
There are disclosed pharmaceutically-active aminoglycosides comprising 4-O-(2',6'-diamino 2',6'-didesoxy .alpha.,D-glucopyrannosyl) 6-O-(3"-amino 3",4",6"-tridesoxy .alpha., D-xylohexopyrannosyl) 2-desoxy streptamine of the formula: ##STR1## and the addition salts thereof with mineral acids or organic acids. Also disclosed are methods for preparation of the novel products as well as certain novel intermediate products. There are also disclosed pharmaceutical compositions in which the novel products are the active agents as well as methods for use of compositions as antibiotic agents.

REFERENCES:
patent: 3350387 (1967-10-01), Vanderhaeghe
patent: 3925353 (1975-12-01), Umezawa et al.
patent: 3925354 (1975-12-01), Umezawa et al.
patent: 3959255 (1976-05-01), Chazan et al.
Kojima et al., "The Jour. of Antibiotics" vol. XXVI, No. 12, pp. 784-785, 1973.

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