Antibiotic amino acid derivatives of cephalosporins

Details Antibiotic amino acid derivatives of cephalosporins Antibiotic amino acid derivatives of cephalosporins

1983-10-11

1986-08-12

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514204, 514209, 540215, 540222, 540223, 540224, 540226, A61K 31545, C07D50136

Patent

active

046056513

ABSTRACT:
1. A cephalosporin derivatives of the general formula ##STR1## wherein R.sup.1 is an .alpha.-, .beta.- or .gamma.-amino acid residue (bonded by the ester linkage), which may optionally be substituted by one or two lower alkyl groups at the amino group thereof, R.sup.2 is an 1-alkanoyloxyalkyl, 1-alkoxycarbonyloxyalkyl, phthalidyl or 5-methyl-1,3-dioxolen-2-on-4-ylmethyl group, R.sup.3 is a carbamoyloxymethyl group, which may optionally be substituted by one or two lower alkyl groups, or a heterocyclothiomethyl group, which may optionally be substituted by one or more appropriate substituents, and R.sup.4 is a hydrogen atom or a hydroxy group, or its non-toxic salt are found to be useful as orally administrable antibiotics having broad antimicrobial activities against both gram-positive and gram-negative bacteria.

REFERENCES:
patent: 3701775 (1972-10-01), Berges
patent: 3812116 (1974-05-01), Takano et al.
patent: 4041161 (1977-09-01), Kocsis
patent: 4107433 (1978-08-01), Bentley

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