Antibiotic A 40926 complex and its pure factors PA, PB, A, B and

Details Antibiotic A 40926 complex and its pure factors PA, PB, A, B and Antibiotic A 40926 complex and its pure factors PA, PB, A, B and

1985-10-09

1990-06-19

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424119, 424115, 435169, 435170, A61K 3574, C12P 106, C12P 104

Patent

active

049352385

ABSTRACT:
The present invention concerns a new antibiotic substance arbitrarily denominated antibiotic A 40926 complex and its factors antibiotic A 40926 factor A, antibiotic A 40926 factor B, antibiotic A 40926 factor B.sub.0, antibiotic A 40926 factor PA and antibiotic A 40926 factor PB, a process for producing them by culturing the new strain Actinomadura sp. ATCC 39727 or an A 40926 producing variant or mutant thereof and the use of these new antibiotic substances in the treatment of infectious diseases involving microorganisms susceptible to them. The antibiotic substances of the invention are glycopeptidic substances belonging to the vancomycin class of antibiotics which have binding capacity to Acyl-D-Alanyl-D-Alanine.

REFERENCES:
L. J. Nisbet, et al., Discovery, Comparative Antibacterial Activity and Structure Elucidation of AAJ-271, A Novel Group of Glycopeptides, Twenty-Sixth Interscience Conference on Antimicrobial Agents and Chemotherapy, Sep. 28-Oct. 1, 1986, New Orleans, La. abstract no. 226.

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