Antibiotic A/16686 recovery process

Details Antibiotic A/16686 recovery process Antibiotic A/16686 recovery process

1995-05-18

1996-07-23

Fleisher, Mindy

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530300, 530317, 530322, 530344, 530418, 530419, 530421, 435 711, 435 713, C07K 114, C07K 130, A61K 3812, C12P 2104

Patent

active

055390870

ABSTRACT:
The present invention is directed to a process for recovering the antibiotics produced by fermentation of Actinoplanes sp. ATCC 33076 or a producing mutant thereof, from a fermentation broth or a process stream, which comprises extraction of the antibiotics by a non-ionic surfactant or a cationic surfactant miscible with or dispersable in water and capable of dissolving the antibiotics, formation of two phases in the first of which the antibiotic and the surfactant are present together, and separation of the antibiotic from the surfactant by addition of suitable organic solvents.

REFERENCES:
patent: 4245047 (1981-01-01), Higashide et al.
patent: 4298600 (1981-11-01), Higashide et al.
patent: 4347322 (1982-08-01), Johnson et al.
patent: 4695545 (1987-09-01), Nakatsukasa
patent: 4713331 (1987-12-01), Michel et al.
patent: 5024937 (1991-06-01), Penticoff et al.
Bardone, et al. "Teichomycins, New Antibiotics from Actinoplanes Teichomycticus Nov. Sp." J. Antibiotics 31(3): 170-177 1978.
Cavalleri, et al. "A-16686, A New Antibiotic from Actinoplanes" J. Antibiotics 37(4) 309-317 1984.
Derwent Abstract No. 364736/50.

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