Antibiotic 9-acyl-3"-thiomethoxymethyl-SF-837 composition and pr

Details Antibiotic 9-acyl-3"-thiomethoxymethyl-SF-837 composition and pr Antibiotic 9-acyl-3"-thiomethoxymethyl-SF-837 composition and pr

1973-03-28

1977-06-14

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 17, C07H 1708

Patent

active

040298817

ABSTRACT:
A new derivative of the macrolide antibiotic SF-837 substance is manufactured by treating a 9,2'-diacyl- or 9-acyl-SF-837 composition with dimethylsulfoxide and acetic anhydride, and, subsequently, with an alcohol or water-containing solvent to yield the novel compound, 9-Acyl-3"-thiomethoxymethyl-SF-837 composition. In addition to high therapeutic effectiveness and low acute toxicity, this novel compound of the present invention has the great advantages that it does not have the bitter taste originally accompanying the parent compounds, and the further advantage that it is suitable for pediatric and veterinary use.

REFERENCES:
patent: 3792035 (1974-02-01), Fukatsu et al.
patent: 3853842 (1974-12-01), Kishi et al.
patent: 3855202 (1974-12-01), Omoto et al.

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