Antibiotic 107891, its factors A1 and A2, pharmaceutically...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07351687

ABSTRACT:
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation ofMicrobisporasp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such asM. catharralis, Neisseriaspecies andH. influenzaeand Mycobacteria.

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Sahl, H-G. et al. “Lantibiotics : Biosynthesis and Biological Activities of Uniquely Modified Peptides from Gram-Positive Bacteria” Ann. Rev. Microbiol. 52:41-79 (1998).
Xu, S-Z. et al. “Isolation of the genus Microbispora from soil of China” Weishengu Xuebao 19(3): 255-58 (1979).

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