Antibiotic 107891, its factors A1 and A2, pharmaceutically...

Details Antibiotic 107891, its factors A1 and A2, pharmaceutically... Antibiotic 107891, its factors A1 and A2, pharmaceutically...

2008-04-01

2008-04-01

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07351687

ABSTRACT:
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation ofMicrobisporasp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such asM. catharralis, Neisseriaspecies andH. influenzaeand Mycobacteria.

REFERENCES:
patent: 6551591 (2003-04-01), Lee
patent: 0 592 835 (1994-04-01), None
patent: 59 198982 (1984-11-01), None
Database WPI Section Ch, Week 198451, Derwent Publications Ltd, London, GB, AN 1984-316058.
Hayakawa, M. et al. “Distribution of antibiotic-producing Microbispora strains in soils with different pHs” ACTINOMYCETES 6(3): 75-79 (1995).
Lazzarini, A. et al. “Rare genera of actinomycetes as potential producers of new antibiotics” antonie Van Leeuwenhoek 78(3-4): 399-405 (Dec. 2000).
McAuliffe, O. et al. “Lantibiotics: structure, biosynthesis and mode of action” FEMS Microbiology Reviews 25(3): 285-308 (May 2001).
Sahl, H-G. et al. “Lantibiotics : Biosynthesis and Biological Activities of Uniquely Modified Peptides from Gram-Positive Bacteria” Ann. Rev. Microbiol. 52:41-79 (1998).
Xu, S-Z. et al. “Isolation of the genus Microbispora from soil of China” Weishengu Xuebao 19(3): 255-58 (1979).

Affiliated with

Also associated with

Rating

Antibiotic 107891, its factors A1 and A2, pharmaceutically... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotic 107891, its factors A1 and A2, pharmaceutically..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotic 107891, its factors A1 and A2, pharmaceutically... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2759756