Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-22
1999-01-26
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514774, 514784, A61K 3134, A61K 4700
Patent
active
058639381
ABSTRACT:
This invention pertains to therapeutic antibacterial-wound healing compositions. The compositions comprise a therapeutically effective amount of an antibacterial agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antibacterial-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antibacterial-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
REFERENCES:
patent: 3887702 (1975-06-01), Baldwin
patent: 3920835 (1975-11-01), Van Scott et al.
patent: 3984566 (1976-10-01), Van Scott et al.
patent: 3988470 (1976-10-01), Van Scott et al.
patent: 4105783 (1978-08-01), Yu et al.
patent: 4158057 (1979-06-01), Stanko
patent: 4170821 (1979-10-01), Booth
patent: 4197316 (1980-04-01), Yu et al.
patent: 4234599 (1980-11-01), Van Scott et al.
patent: 4246261 (1981-01-01), Van Scott et al.
patent: 4284630 (1981-08-01), Yu et al.
patent: 4294852 (1981-10-01), Wildnauer et al.
patent: 4351835 (1982-09-01), Stanko
patent: 4363815 (1982-12-01), Yu et al.
patent: 4415576 (1983-11-01), Stanko
patent: 4416982 (1983-11-01), Tsuda et al.
patent: 4451482 (1984-05-01), Cagen
patent: 4454159 (1984-06-01), Musher
patent: 4496536 (1985-01-01), Moller
patent: 4521375 (1985-06-01), Houlsby
patent: 4533637 (1985-08-01), Yamane
patent: 4548937 (1985-10-01), Stanko
patent: 4615697 (1986-10-01), Robinson
patent: 4645764 (1987-02-01), Stanko
patent: 4663166 (1987-05-01), Veech
patent: 4696917 (1987-09-01), Lindstrom et al.
patent: 4725586 (1988-02-01), Lindstrom et al.
patent: 4734276 (1988-03-01), Ziegler
patent: 4812479 (1989-03-01), Stanko
patent: 4847069 (1989-07-01), Bissett et al.
patent: 4847071 (1989-07-01), Bissett et al.
patent: 4847072 (1989-07-01), Bissett et al.
patent: 4874603 (1989-10-01), Fratzer
patent: 5084482 (1992-01-01), Hirsch et al.
patent: 5296307 (1994-03-01), Martin et al.
Reynolds, J.E.F., "Phenol," Martindale, The Extra Pharmacopeia, Twenty-ninth edition, 1989, pp. 967-968.
Reynolds, J.E.F., "Povidone-Iodine," Martindale, The Extra Pharmacopeia, Twenty-ninth edition, 1989, pp. 1187-1188.
Giannelli, S. Jr., et al. (May 1976). Prevention of increased hemoglobin-oxygen affinity in open-heart operations with inosine-phosphate-pyruvate solution. Annals of Thoracic Surgery, vol. 21, No. 5, pp. 386-396.
Freese, E., et al. (1971). Molecular mechanisms of mutations. In Chemical Mutations(A. Hollander, ed.), Plenum Press, New York-London, pp. 46-48.
Marchek, A. C., et al. (Jun. 1977) Increased in vitro growth capacity of tracheal epithelium exposed in vivo to 7, 12 dimethylbenz(a)anthracene. Cancer Research, vol. 37, pp. 1811-1921.
Schwartz, C., et al. (May 7, 1979). Antagonism of cyanide intoxication with sodium pyruvate. Toxicology and Applied Pharmacology, vol. 50, pp. 437-441.
Ahmed, A. M., et al. (1979). Effects of ascorbic acid and various keto-acids on the glyoxalase enzyme system in mouse and rat liver. IRCS Medical Science, vol. 7, pp. 505.
Mochizuki, S., et al. (1980). Energy metabolism during reperfusion following ischemia. J. Physiol., Paris, vol. 76, pp. 805-812.
Cohen, M. H., (Spring, 1981). Cure of advanced L1210 leukemia after correction of abnormal red blood cell deformability. Cancer Chemother. Pharmacol., vol. 5, pp. 175-179.
Regitz, V., et al. (1981). Biochemical mechanism of infarct size reduction by pyruvate. Cardiovascular Res. vol. 15, pp. 652-658.
Wolters, M., et al. (1982). The effect of x irradiation on survival of mammalian cells substituted by poly unsaturated fatty-acids. Radiat. Res., vol. 92 (3), pp. 474-482.
Puschmann, V. M. (1983). Animal experimental examinations of the gastric mucosa and demonstration of the analgetic and antipyretic effect after combined application of acetylsalicylic acid and sodium pyruvate. Arzneim-Forsch/Drug Res., vol. 33 (I), nr. 3, pp. 410-415.
Puschmann, V. M., et al. (1983). Double-blind controlled gastroscopic comparative study on lesions of the gastric mucosa in healthy volunteers after treatment with acetylsalicylic acid or acetylsalicylic acid/sodium pyruvate. Arzneim-Forsch/Drug Res., vol. 33(I), nr. 33, pp. 415-416.
Subramanyam, K. (Sep. 1984). Effects of Preparation-H on wound healing in the rectum of man. Digestive Diseases and Sciences, vol. 29, No. 9, pp. 829-832.
Bunger, R., et al. (1986). Pyruvate attenuation of hypoxia damage in isolated working guinea-pig heart. J. Mol Cell Cardiol, vol. 18, pp. 423-438.
Andrae, U., et al. (1985). Pyruvate and related a-ketoacids protect mammaliancells in culture against hydrogen peroxide-induced cytotoxicty. Toxicology Letters, vol. 28, pp. 93-98.
Cohen, J., et al. (Jun. 1985). Pregnancies following the frozen storage of expanding human blastocycsts. J. of in Vitro Fertilization and Embryo Transfer, vol. 2, No. 2., pp. 59-64.
Davis, D. L. (1985). Culture and storage of pig embroys. J. Reprod. Fert. Suppl., vol. 33, pp. 115-124.
Ogawa, Y., et al. (Sep. 1986). Comparative study of the effects of pyruvate and CG-120 in preventing experimental oxalate urolithiasis in rats. Acta Urol. Jpn., vol. 32, No. 9, pp. 1341-1347.
Shacter, E. (1987). Serum-free medium for growth factor-dependent and indepenent plasmacytomas and hybridomas. J. of Immunological Methods, vol. 99, pp. 259-270.
Varma, S. D., et al. (1988). Peroxide damage to the eye lens in vitro prevention by pyruvate. Free Rad. Res. Comms., vol. 4, No. 5, pp. 283-290.
O'Donnell-Tormey, J., et al., (Feb. 1967). Secretion of pyruvate, an antioxidant defense of mammalian cells. J. Exp. Med., vol. 165, pp. 500-514.
Sabri, M. I., et al. (1989). Effect of exogenous pyruvate on acrylamide neuropathy in rats. Brain Research, vol. 483, pp. 1-11.
Mentzer, R. M., et al. (Apr. 1988). Effect of pyruvate on regional ventricular function in normal and stunned myocardium. Ann. of Surgery, vol. 209, No. 4, pp. 629-634.
Martin, A., et al. (1990). A resuscitation/selection system for rapid determination of salmonella in foods. J. Assoc. Off. Anal. Chem., vol. 74, No. 3, pp. 522-525.
Martin, A., et al. (1990). A resuscitation medium for rapid recovery and isolation of injured salmonella, escherichia coli, staphylococcus aureus, and listeria in food. (unpublished Ph.D. dissertation, Rutgers Univ., N. J.).
Salahudeen, A. K., at al. (1991). Hydrogen peroxide-induced renal injury, a protective role for pyruvate in vitro and in vivo. J. Clin. Invest., vol. 88, pp. 1886-1893.
Barish Jean B.
Criares Theodore J.
Warner & Lambert Company
LandOfFree
Antibacterial-wound healing compositions and methods for prepari does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibacterial-wound healing compositions and methods for prepari, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibacterial-wound healing compositions and methods for prepari will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1450766