Antibacterial quinoline derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S176000

Reexamination Certificate

active

07915292

ABSTRACT:
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib):the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of a bacterial disease including a mycobacterial disease, particularly those diseases caused by pathogenic mycobacteria such asMycobacterium tuberculosis, M. bovis, M. aviumandM. marinum. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of bacterial diseases and a process for preparing the claimed compounds.

REFERENCES:
patent: 01063518 (1989-03-01), None
patent: WO 2004/011436 (2004-02-01), None
Wolff, Manfred E. “Burger's Medicinal Chemistry and Drug Discovery, 5ed, vol. 1” John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutices, 3ed.” Marcel Dekker, New York, 1996, pp. 451 and 596.
International Search Report dated Oct. 6, 2006 for related International Application No. PCT/EP2006/064656.

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