Antibacterial polypeptides

Details Antibacterial polypeptides Antibacterial polypeptides

1990-05-31

1992-03-17

Doll, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3702, C07K 710, C07K 302, C07K 1300

Patent

active

050968866

ABSTRACT:
A polypeptide having bactericidal activity, particularly against gram-negative bacteria, has been isolated from pig intestine. The porcine cecropin has the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-AlaLys-Lys-Arg-Ile-S er-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COOh. Pharmaceutical compositions containing such poypeptides, or functional derivatives thereof, are useful in therapeutic and prophylactic methods for inhibiting bacterial growth.

REFERENCES:
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 4810777 (1989-03-01), Zasloff
patent: 4962277 (1990-10-01), Cuervo et al.
Hultmark et al., "Insect Immunity", The EMBO Journal 2: 571-576, 1983.

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