Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1992-02-07
1994-08-09
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
A61K 3700, A61K 3702, C07K 500, C07K 700
Patent
active
053367570
ABSTRACT:
A novel peptide, polydiscamide A, has been isolated from a marine sponge. This compound, and its derivatives, are useful as antibacterial agents.
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Matsunaga, S. N. Fusetani, S. Konosu (1984) "Bioactive Marine Metabolites VI. Structure Elucidation of Discodermin A, an Antimicrobial Peptide from the Marine Sponge Discodermia kiiensis," Tetrahedron Letters 25(45):5165-5168.
Matsunaga, S., N. Fusetani, S. Konosu (1985) "Bioactive Marine Metabolites VII. Structures of Discodermins B, C, and D, Antimicrobial Peptides from the Marine Sponge Discodermia kiiensis," Tetrahedron Letters 26(7):855-856.
Gulavita Nanda K.
Gunasekera Sarath P.
Longley Ross E.
McCarthy Peter J.
Pomponi Shirley A.
Davenport A. M.
Harbor Branch Oceanographic Institution Inc.
Lee Lester L.
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