Antibacterial oxalidinones

Details Antibacterial oxalidinones Antibacterial oxalidinones

2007-03-06

2007-03-06

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S359000, C514S403000, C514S372000, C514S378000, C514S361000, C548S229000, C548S255000, C548S247000, C548S206000, C548S364100

Reexamination Certificate

active

10550038

ABSTRACT:
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl, substituted with: T is for example selected from (TAa1 to TAa12) such as (TAa1) and (TAa5): R4h, R5h, R6hare for example selected from hydrogen, (1–4C)alkyl, (1–4C)alkoxy-carbonyl, (1–4C)alkanoyl and carbamoyl; processes for making them, compositions containing them and their use as antibacterial agents are described.

REFERENCES:
patent: 2006/0084810 (2006-04-01), Gravestock et al.
patent: WO 01/81350 (2001-11-01), None
patent: WO 03/035648 (2003-05-01), None
patent: WO 03/072575 (2003-09-01), None
Lee S C et al : “Carbon-carbon linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria” Bioorganic and Medicinal Chemistry, vol. 9, No. 12, Dec. 2001, pp. 3243-3253, XP002283682 the whole document.
Phililips O A et al : “Synthesis and antibacterial activity of 5-substituted oxazolidinones” Bioorganic and Medicinal Chemistry, vol. 11, No. 1, Jan. 2, 2003, pp. 35-41, XP002283683 the whole document.

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