Antibacterial oral composition

Drug – bio-affecting and body treating compositions – Dentifrices – Ammonia – amine – or derivative thereof

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A61K 722, A61K 724

Patent

active

040804410

ABSTRACT:
An antibacterial oral composition effective to promote oral hygiene containing an antibacterial antiplaque agent and an additive which reduces staining of dental surfaces without substantially diminishing the antibacterial and antiplaque activity of the agent. Bis-biguanido hexanes, such as chlorhexidine and alexidine, and quaternary ammonium salts, such as benzethonium chloride and cetyl pyridinium chloride, are typical examples of antibacterial agents. The antistain additive is a bis(o-carboxyphenyl)ester of a C.sub.2-8 aliphatic dicarboxylic acid such as bis(o-carboxyphenyl)succinate.

REFERENCES:
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patent: 3671626 (1972-06-01), Felger
patent: 4013714 (1977-03-01), Lannert
Zaugg et al., Biochem. Biophys. Res. Comm. 64(4):1192-1198 (1975).
Delphant, Compt. Rend. Soc. Biol. 147:834-836, 1456-1458 (1953).
Bastide et al., Trans. Soc. Pharm. Montpellier 3(4):178-181 (1953).
Bastide, Therapie 10:700-707 (1955).
Dastague et al., Therapie 15:715-722 (1960).
C.A. 84 No. 164186a (1976) of U.S. Publ. Pat. App. B 426157.

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