Antibacterial compounds

Details Antibacterial compounds Antibacterial compounds

2005-11-15

2005-11-15

Huang, Evelyn Mei (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S232800, C546S085000, C546S086000, C546S087000, C544S126000

Reexamination Certificate

active

06964970

ABSTRACT:
Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections:wherein:R1is Ar or Het;R2is H, C1-6alkyl or Ar-C0-6alkyl;X is H, C1-4alkyl, OR′, SR′, C1-4alkylsulfonyl, C1-4alkylsulfoxyl, CN, N(R′)2, CH2N(R′)2, NO2, CF3, CO2R′, CON(R′)2, COR′, NR′C(O)R′, F, Cl, Br, I, or CF3S(O)r—;R′ is H, C1-6alkyl or Ar-C0-6alkyl; andr is 0, 1 or 2;or a pharmaceutically acceptable salt thereof.

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