Antibacterial composition comprising silver sulfadiazine and sod

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Para-n-benzene - sulfoxy-n containing doai – and said benzene...

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514253, 514495, A61K 31429, A61K 31625

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active

045350787

ABSTRACT:
An antibacterial composition useful in burn therapy comprises silver sulfadiazine, sodium piperacillin and a physiologically acceptable carrier.

REFERENCES:
patent: 4112090 (1978-09-01), Saikawa et al.
"Piperacillin, a New Penicillin Active Against Many Bacteria Resistant to Other Penicillins", Fu et al., vol. 13, No. 3, Mar., 1978, Antimicrobial Agents and Chemotherapy, pp. 358-367.
Modak et al., "Control of Burn Wound Infections by Pefloxacin and its Silver Derivative", Burns, vol. 10, No. 3, pp. 170-178, (1983).
McManus et al., "Burn Wound Infection", The Journal of Trauma, vol. 21, No. 9, pp. 753-756, Sep. 1981.
Heggers et al., "Cerium Nitrate/Silver Sulphadiazine: Synergism or Antagonism as Determined by Minimum Inhibitory Concentration", Burns, vol. 5, No. 4, pp. 308-311, (1978).
Fox et al., "Virulence of Pseudomonas Infection in Burned Rats and Mice", Archives of Surgery, vol. 101, pp. 508-512, Oct. 1970.
Snelling et al., "Resistance of Gram-Negative Bacilli to Gentamicin", The Journal of Infectious Diseases, vol. 124, Supplement, pp. S264-S270, Dec. 1971.
Stone et al., "The Evolution and Spread of Gentamicin-Risistant Pseudomonads", The Journal of Trauma, vol. 11, No. 7, pp. 586-589, 1971.
Shulman et al., "Colonization with Gentamicin-Resistant Pseudomonas Aeruginosa, Pyocine Type 5, in a Burn Unit", The Journal of Infectious Diseases, vol. 124, Supplement, pp. S18-S23, Dec. 1971.
Chadwick, "Resistance of Pseudomonas Aeruginosa to Gentamicin", CMA Journal, vol. 109, pp. 585-587, Oct. 6, 1973.
Bryan et al., "Gentamicin Resistance in Pseudomonas Aeruginosa: R-Factor-Mediated Resistance", Antimicrob. Ag. Chemother., vol. 6, No. 2, pp. 191-199, Aug. 1974.
Fox, "Silver Sulfadiazine--A New Topical Therapy for Pseudomonas in Burns", Archives of Surgery, vol. 96, pp. 184-188, Feb. 1968.
Fox et al., "Control of Pseudomonas Infection in Burns by Silver Sulfadiazine", Surgery, Gynecology & Obstetrics; vol. 128, pp. 1021-1026, May, 1969.
Gayle et al., "Resistant Enterobacter Cloacae in a Burn Center: The Ineffectiveness of Silver Sulfadiazine", The Journal of Trauma, vol. 18, No. 4-5, pp. 317-323, May 1978.
Modak et al., "Silver Sulfadiazine (AgSD) Resistant Pseudomonas Infection in Experimental Burn Wounds", Estratto da Panminerva Medica Europa Medica, vol. 25, No. 3, pp. 181-188, (Jul.-Sep. 1983).
Modak et al., "Sulfadiazine Silver-Resistant Pseudomonas in Burns", Archives of Surgery, vol. 116, pp. 854-857, Jul. 1981.

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