Antibacterial carbapenem compounds

Details Antibacterial carbapenem compounds Antibacterial carbapenem compounds

1982-04-20

1984-08-07

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602452R, 260239A, 424270, 424274, A61K 3140, C07G48704

Patent

active

044642997

ABSTRACT:
Antibacterial carbapenem compounds represented by the general formula ##STR1## wherein X is hydrogen or alkyl, A is hydrogen or alkyl, R is hydrogen or a monovalent substituent and COB is carboxy, its pharmaceutically acceptable ester or its alkali metal salt are prepared from the suitably substituted monocyclic 2-azetidinone by a Wittig cyclization or carbene-insertion cyclization to give Compounds(I) or by cleaving the dioxolane ring of above Compounds(I) with a strong base e.g. DEN or DBU to give above Compounds(II). Some other alterations of COB, R and side chain structure are also disclosed.

REFERENCES:
patent: 4292241 (1981-09-01), Tanaka et al.
patent: 4309346 (1982-01-01), Christensen et al.
patent: 4347368 (1982-08-01), Christensen et al.
patent: 4362665 (1982-12-01), Tanaka et al.
patent: 4387052 (1983-06-01), Tanaka et al.

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