Antibacterial beta-lactams, pharmaceuticals thereof and methods

Details Antibacterial beta-lactams, pharmaceuticals thereof and methods Antibacterial beta-lactams, pharmaceuticals thereof and methods

1980-01-24

1989-06-20

Lone, Werren B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540306, 540318, 540336, A61K 3143, C07D49932

Patent

active

048409448

ABSTRACT:
The present invention relates to hitherto unknown compounds of the general formula I: ##STR1## in which R.sub.1 stands for a phenyl, 4-hydroxyphenyl, 1,4-cyclohexadienyl or a 3-thienyl group; R.sub.2 represents a primary amino or a carboxy group; R.sub.3 is a hydrogen atom, or a lower alkyl, aryl or aralkyl radical, and A stands for a radical of a .beta.-lactamase inhibitor containing a .beta.-lactam ring as well as a carboxy group, A being connected via the carboxy group.
The present invention provides new compounds useful in the treatment of bacterial infections. The new compounds are in particular strongly active against .beta.-lactamase producing bacteria.

REFERENCES:
patent: 3838152 (1974-09-01), Hou et al.
patent: 3869449 (1975-03-01), Godtfredsen
patent: 3981865 (1976-09-01), Saikawa et al.
patent: 4181659 (1980-01-01), Hansen
patent: 4244951 (1981-01-01), Bigham

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