Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1996-05-06
1998-08-11
Nazario-Gonzalez, Porfirio
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
106 105, 556113, 556117, 548101, A61K 3128, C07F 108
Patent
active
057927936
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to antibacterial, antifungal, and antiviral agents as well as to compositions containing the agents. More particularly, the present invention relates to antibacterial, antifungal, and antiviral agents having wide antibacterial spectra, resisting against decomposition, exhibiting sustained activities, and being very safe providing reduced skin irritation and mucosa irritation. The invention also relates to compositions which contain the agents and which can be used in a wide variety of industrial fields.
BACKGROUND ART
In recent years, many attempts have been made to exploit compositions exhibiting antibacterial and antifungal activities in the fields of textiles, sanitary goods, tableware, packaging materials, paints, sprays, etc. These compositions acquire a function of providing antibacterial and antifungal activities when chemicals exhibiting antibacterial and antifungal activities are added to, or kneaded together with, a variety of vehicles or carriers.
In order for chemicals exhibiting antibacterial and antifungal activities to be exploited in a wide range of industrial fields, they must be safe and have wide antibacterial and antifungal spectra. Moreover, they must satisfy requirements with respect to compatibility with vehicles and carriers, durability, sustained activities, and economy.
Examples of chemicals used as antibacterial and antifungal agents include benzimidazoles, nitriles, isothiazolines, haloallylsulfones, iodopropargyls, benzthiazoles, phenols, and organic tins, pyridines, diphenylethers, and chlorhexidines.
However, many of these antibacterial and antifungal agents do not provide sufficient antibacterial and antifungal effects. Moreover, even though certain chemicals exhibit exellent antibacterial and antifungal activities, they may not always possess excellent compatibility with vehicles or carriers, and in such cases, they may eventually exhibit only poor antibacterial and antifungal activities when they are actually used in various industrial fields. On the other hand, regarding the safety of these antibacterial and antifungal agents, it is noted that many of them induce peroral toxicity, skin irritation, and mucosa irritation. In general, the stronger the antibacterial and antifungal activity, the more significant these actions. Therefore, in order to exploit compositions containing antibacterial and antifungal agents in everyday life environments, the above problems must be solved.
Accordingly, an object of the present invention is to provide antibacterial, antifungal, and antiviral agents which have wide antibacterial and antifungal spectra, are well compatible with vehicles and carriers, exhibit resistance against decomposition; sustain their activities, and have reduced peroral toxicity, skin irritation, and mucosa irritation effects.
DISCLOSURE OF THE INVENTION
The present inventors conducted extensive studies, and found that a complex formed by the coordination of a thiol-group containing compound with a silver ion exhibits a wide antibacterial and antifungal spectrum and also exhibits antiviral activity, that the complex is well compatible with various vehicles and carriers, and that the complex has significantly reduced toxicity, skin irritation, and mucosa irritation effects, leading to completion of the invention.
Accordingly, the present invention provides a complex formed by the coordination between a thiol-group containing compound and a silver ion.
The present invention also provides an antibacterial, antifungal, and antiviral agent comprising, as an active component, a complex formed by the coordination between a thiol-group containing compound and a silver ion.
The present invention also provides an antibacterial, antifungal, and antiviral composition comprising a complex formed by the coordination between a thiol-group containing compound and a silver ion, as well as a vehicle or a carrier for the complex.
BEST MODE FOR CARRYING OUT THE INVENTION
In the complex of the present invention, the thiol-group cont
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Chemical Abstracts, vol. 112, Abstract No. 213767, 1989.
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Itoh Hiroyuki
Jonoshita Yukiyoshi
Kikuchi Akira
Nomiya Kenji
Oda Munehiro
Meiji Milk Products Co. Ltd.
Nazario-Gonzalez Porfirio
Toyo Ink Mfg. Co. Ltd.
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