Antibacterial and antimalarial hybrid peptides

Details Antibacterial and antimalarial hybrid peptides Antibacterial and antimalarial hybrid peptides

1993-03-26

1998-02-03

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514 2, 530324, 530325, 930 20, A61K 3816, C07K 700

Patent

active

057144672

ABSTRACT:
The invention relates to antibacterial and antimalarial peptides which are hybrids peptides which a of naturally occurring peptides such as cecropins, attacins, magainins, sarcotoxin, sapecin, bactenecins, alamethidicins, defensins and PGLa, and toxins such as streptolysins, melittin, barbatolysin, paradaxins and delta hemolysin. The hybrid peptides of the present invention are easily synthesized and have reduced toxicity. Also included in the invention are pharmaceutical compositions containing such hybrid peptides, and methods of treating patients infected with an organism against which these peptides are active.

REFERENCES:
Gwadz et al, Infection and Immunity, (Sep. 1989), vol. 57(9), pp. 2628-2633.
Christensen et al, Proc. Nat'l. Acad. Sci. USA, vol. 85, pp. 5072-5076, (Jul., 1988).
Roman et al, FEBS, vol. 259(1), pp. 103-106, (Dec. 1989).
Fink et al, Chem. Abs., vol. 111, 97703c; J. Biol. Chem. (1989), vol. 264 (11), pp. 6260-6267.
Boman et al, Chem. Abs., vol. 112(19), 175229m; FEBS Lett., vol. 259(1), pp. 103-106, (1989).
Li et al, FEBS Lett., vol. 231(2), pp. 299-302, (1988).
Boman, Chem. Abs., vol. 109(5), 36438g, (1986).
Jaynes et al, Chem. Abs., vol. 109(19), 165036y, (1988).
Jaynes et al, World Pat. 89-039653.
Kaslow et al, Chem. Abs., vol. 111, 224848f, (1989); Infect. Immun., vol. 57(9), pp. 2628-2633, (1989).
Kaaya et al, Chem. Abs., vol. 106(17), 136837t; Insect Biochemistry, vol. 17(2), pp. 309-315, (1987).
Degrado et al, J. Am. Chem. Soc 1981, 103, 679-681.

Affiliated with

Also associated with

Rating

Antibacterial and antimalarial hybrid peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibacterial and antimalarial hybrid peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibacterial and antimalarial hybrid peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-662409