Antibacterial and antifungal flavanones from Eysenhardtia texana

Details Antibacterial and antifungal flavanones from Eysenhardtia texana Antibacterial and antifungal flavanones from Eysenhardtia texana

1999-10-06

2000-10-24

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549403, A61K 3135, C07D31132

Patent

active

061368490

ABSTRACT:
An activity-guided fractionation of a methanol-dichloromethane extract obtained from the aerial parts of Eysenhardtia texana Kunth. (Fabaceae) led to the isolation of two new antibacterial and antifungal flavanones. Their structures were established as 4',5,7-trihydroxy-8-methyl-6-(3-methyl-[2-butenyl])-(2S)-flavanone and 4',5,7-trihydroxy-6-methyl-8-(3-methyl-[2-butenyl])-(2S)-flavanone on the basis of their UV, ID and 2D-NMR spectra. These compounds have potent antibacterial and antifungal activity as measured by bioassay.

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Chem. Abstr,, vol. 128, No. 2, Abstr. No. 13147q, Jpn Kokai 09-301915, May 1996, 1998.
Iinuma et al, J. Pharm. Phamacology, vol. 46, p. 892-895, 1994.

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