Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)

Details Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl) Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)

1980-01-30

1981-06-16

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424273R, 542405, 542440, 542458, 546278, 548336, 548341, 568336, A61K 3144, A61K 31415, C07D23360, C07D40906

Patent

active

042737761

ABSTRACT:
Compounds are provided having the structure ##STR1## wherein R.sup.1 is lower alkyl; phenyl-lower alkyl; phenyl; substituted phenyl wherein the phenyl group bears one or two halogen, hydroxy, lower alkyl, lower alkoxy, lower alkylothio, cyano or nitro groups; 5- or 6-membered monocyclic aromatic heterocyclics containing one hetero atom, namely, O, S or N, such as furanyl, pyridinyl or thiophenyl; and substituted heterocyclics wherein any of the above heterocyclics bears one halogen, hydroxy, lower alkyl, lower alkoxy, lower alkylthio, cyano or nitro group;

REFERENCES:
patent: 3721668 (1973-03-01), Rufer et al.
patent: 3753983 (1973-08-01), Raabe et al.
patent: 3929819 (1975-12-01), Inazuka et al.
patent: 4067989 (1978-01-01), Shephard et al.
patent: 4107320 (1978-08-01), Grivsky
patent: 4182862 (1980-01-01), Chan
Chemical Abstracts, 89:59889n (1978), [German OLS 2,738,640, Lewis et al., 03/02/78].
Chemical Abstracts, 67:32647n (1967), [Hoffmann et al., 2. Chem., 7 (1), 12 (1967)].
Godefroi, E., et al., J. Med. Chem., 12, 784-791 (1969).

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