Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-03-02
1983-05-03
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602391, 546156, 546157, A61K 3147, C07D49970, C07D21556
Patent
active
043820891
ABSTRACT:
Novel organic amide compounds which are N-[[(acylaminoacylamino or aminoacylamino9]-dihydro-oxo-3-quinolinylcarbonyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding (acylaminoacylamino or aminoacylamino)-dihydro-oxo-3-quinolinecarboxylic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[(acylaminoacylamino or aminoacylamino) dihydro-oxo-3-quinolinycarbonyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
REFERENCES:
patent: 3864329 (1975-02-01), Tobiki et al.
patent: 3907808 (1975-09-01), Lesher et al.
patent: 4263302 (1981-04-01), Matsubara et al.
patent: 4267180 (1981-05-01), Haskell et al.
patent: 4273932 (1981-06-01), Matsubara et al.
patent: 4278681 (1981-07-01), Haskell et al.
Haskell Theodore H.
Hutt Marland P.
Clarke Vera C.
Daignault Ronald A.
Trousof Natalie
Warner-Lambert & Company
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