Antibacterial amide compounds and pharmaceutical composition con

Details Antibacterial amide compounds and pharmaceutical composition con Antibacterial amide compounds and pharmaceutical composition con

1980-09-24

1982-02-09

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602391, 424266, 546261, 546288, 546293, A61K 3144, C07D49970, C07D21176, C07D21364

Patent

active

043150144

ABSTRACT:
Novel organic amide compounds which are N-[6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

REFERENCES:
patent: 3873523 (1975-03-01), Doub et al.
patent: 3951955 (1976-04-01), Tobiki et al.
patent: 4031230 (1977-06-01), Gottschlich et al.
patent: 4092309 (1978-05-01), Mich
patent: 4101661 (1978-07-01), Kaltenbronn et al.

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