Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1980-01-31
1981-07-14
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
2602391, 546298, A61K 31455, C07D49968
Patent
active
042786819
ABSTRACT:
Novel organic amide compounds which are N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl] penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)-phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(acylaminoacylamino or aminoacylamino) phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
REFERENCES:
patent: 3873523 (1975-03-01), Doub et al.
patent: 3954734 (1976-05-01), Doub et al.
patent: 4053470 (1977-10-01), Doub et al.
patent: 4092309 (1978-05-01), Mich
Haskell Theodore H.
Huang Gin G.
Hutt, Jr. Marland P.
Nicolaides Ernest D.
Woo Peter W. K.
Clarke Vera C.
Raines Stephen
Trousof Natalie
Warner-Lambert Co.
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