Antibacterial amide compounds

Details Antibacterial amide compounds Antibacterial amide compounds

1980-09-24

1982-02-16

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424263, 424266, 546276, 546287, 546288, 546298, C07D49970, C07D40112, C07D21364

Patent

active

043158587

ABSTRACT:
Novel organic amide compounds which are N-[6-(acylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[acylaminophenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[acylaminophenyl]-1,2-dihydro-2-oxonicotinoyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

REFERENCES:
patent: 3873523 (1975-03-01), Daub et al.
patent: 3951955 (1976-04-01), Tobiki et al.
patent: 4031230 (1977-06-01), Gottschlich et al.
patent: 4092309 (1978-05-01), Mich
patent: 4101661 (1978-07-01), Kaltenbronn et al.

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