Antibacterial agents

Details Antibacterial agents Antibacterial agents

2007-03-06

2007-03-06

Habte, Kahsay (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C546S188000, C546S193000, C546S196000, C546S207000, C546S214000, C546S221000, C544S129000, C544S133000, C514S237200, C514S256000, C514S337000, C514S318000, C514S336000, C514S320000

Reexamination Certificate

active

10953788

ABSTRACT:
Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1represents hydrogen, C1–C6alkyl or C1–C6alkyl substituted by one or more halogen atoms, or, except when Q is a radical of the formula: —N(OH)CH(═O), a hydroxy, C1–C6alkoxy, C1–C6alkenyloxy, amino, C1–C6alkylamino, or di-(C1–C6alkyl)amino group; R2represents a substituted or unsubstituted C1–C6alkyl, cycloalkyl(C1–C6alkyl)- or aryl(C1–C6alkyl)-group; and A represents a group of formula (IIA), or (IIB) wherein R4represents the side chain of a natural or non-natural alpha amino acid, and R5and R6when taken together with the nitrogen atom to which they are attached form a saturated heterocyclic first ring of 5 to 7 atoms as specified in the description.

REFERENCES:
patent: 6787522 (2004-09-01), Hunter et al.
patent: 08053403 (1996-02-01), None
patent: 91/02716 (1991-03-01), None
patent: 99/39704 (1999-08-01), None
patent: 99/57097 (1999-11-01), None
Broughton, et al.: “Studies Concerning the Antibiotic Actinonin”, J. Chem. Soc., Perkin Trans 1, vol. 9, 1975, pp. 857-860, XP002157880, XP002157880.
Devlin, John P., et al: “Antibiotic actinonin, V. Synthesis of structural analogs of actinonin b the anhydride-ester method”, J.Chem.Soc., Perkin Trans. 1 (1975),(9), 846-848, XP002157881.
Penning, Thomas D., et al.: “Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase”, Bioorg. Med. Chem. Lett. (1995), 5(21), 2157-2522,XP002157882.
Chen, et al.: “Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor”, BIOCHEMISTRY, vol. 39, Feb. 15, 2000, pp. 1256-1262, XP002158085.
Inaoka, et al.: “Propioxatins A and B, new enkephalinase B inhibitors”, J.Biochem. (Tokyo), vol. 104, 1988, pp. 706-711, XP000978993, table I, compd 4.
Bouboutou, et al.: “Inhibition of porcine synovial collengenase by actinonin and derivatives” Colloq. Inserm., vol. 174, 1989, pp. 341-344, XP000978992, Table I, Actinonin 2.
Inaoka, et al.: “propioxatins A and B, new enkephalinase B inhibitors”, J. Antiobiot., vol. 39, No. 10, 1986, pp. 1382-1385, XP000978947.

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