Antibacterial agents

Details Antibacterial agents Antibacterial agents

2007-03-20

2007-03-20

Zucker, Paul A (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S247000, C514S403000, C540S545000, C540S554000, C540S604000, C540S605000, C544S224000, C548S356100

Reexamination Certificate

active

10537346

ABSTRACT:
Compounds of formula (I) have antibacterial activity; wherein Q represents a radical of formula —N(OH)CH(═O) or formula —C(═O)NH(OH); Y represents —C(═O)—, —C(═S)—, —S(═O)—, or —SO2—; R1represents hydrogen, C1–C6alkyl or C1–C6alkyl substituted by one or more halogen atoms, or, except when Q is a radical of formula —N(OH)CH(═O), a hydroxy, C1–C6alkoxy, C1–C6alkenyloxy, halogen, amino, C1–C6alkylamino, or di-(C1–C6alkyl)amino group; R2represents a substituted or unsubstituted C1–C6alkyl, C1–C3alkyl-O—C1–C3alkyl, C1–C3alkyl-S—C1–C3alkyl, cycloalkyl(C1–C3alkyl)-, aryl(C1–C3alkyl)-, heterocyclyl(C1–C3alkyl)-, or R1R2N—C1–C3alkyl group wherein R1represents hydrogen or C1–C3alkyl and R2represents C1–C3alkyl, or R1R2N-represents a cyclic amino group; R3and R4taken together with the nitrogen atoms to which they are respectively attached form a saturated heterocyclic ring of from 4 to 7 ring atoms, which may be fused to a second carbocyclic or heterocyclic ring, either of which rings may optionally be substituted; and A represents a primary, secondary or tertiary amino group or a group —R5, —OR5, wherein R5is a substituted or unsubstituted C1–C6alkyl, C2–C6alkenyl, C2–C6alkynyl, cycloalkyl, aryl, heterocyclyl, C1–C3alkyl-O—C1–C3alkyl, C1–C3alkyl-S—C1–C3alkyl, cycloalkyl(C1–C3alkyl)-, heterocyclic(C1–C3alkyl, aryl(C1–C3alkyl)-or R1R2N—C1–C3alkyl group wherein R1represents hydrogen or C1–C3alkyl and R2represents C1–C3alkyl, or R1R2N-represents a cyclic amino group

REFERENCES:
patent: WO 95 29892 (1995-11-01), None
patent: WO 95 33731 (1995-12-01), None
K. Tamaki et al.: “Synthesis and Structure-Activity Relationships of Gelatinase Inhibitors” Chemical and Pharmaceutical Bulletin., vol. 43, No. 11, 1995, pp. 1883-1893, XP002165817 Pharmaceutical Societe of Japan. Tokyo., JP, ISSN: 0009-2363 p. 1883; example 29-31.

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