Antibacterial agents

Details Antibacterial agents Antibacterial agents

2005-01-25

2005-01-25

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S253010, C514S254030, C514S254040, C514S249000, C544S360000, C544S383000, C544S367000, C544S371000, C544S372000, C544S376000, C544S379000, C544S374000, C544S386000, C544S353000, C546S188000, C546S193000, C546S196000, C546S207000, C546S214000, C546S221000

Reexamination Certificate

active

06846825

ABSTRACT:
Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1represents hydrogen, C1-C6alkyl or C1-C6alkyl substituted by one or more halogen atoms, or, except when Q is a radical of the formula: —N(OH)CH(═O), a hydroxy, C1-C6alkoxy, C1-C4alkenyloxy, amino, C1-C4alkylamino, or di-(C1-C6alkyl)amino group; R2represents a substituted or unsubstituted C1-C6alkyl, cycloalkyl(C1-C6alkyl)- or aryl(C1-C6alkyl)-group; and A represents a group of formula (IIA), or (IIB) wherein R4represents the side chain of a natural or non-natural alpha amino acid, and R5and R6when taken together with the nitrogen atom to which they are attached form a saturated heterocyclic first ring of 5 to 7 atoms as specified in the description.

REFERENCES:
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Broughton, et al.: “Studies Concerning the Antibiotic Actinonin”, J. Chem. Soc., Perkin Trans 1, vol. 9, 1975, pp. 857-860, XP002157880, XP002157880.
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