Antibacterial agents

Details Antibacterial agents Antibacterial agents

2011-08-02

2011-08-02

Lewis, Patrick (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S043000, C514S046000, C514S047000, C514S048000, C536S023100, C536S025300, C536S026100, C536S026700, C536S027100, C536S027130

Reexamination Certificate

active

07989430

ABSTRACT:
The invention provides compounds of formula (I) and salts thereof: R1-L-R2—B wherein R1, L, R2, and B have any of the values defined herein, as well as compositions comprising such compounds, and therapeutic methods comprising the administration of such compounds or salts. The compounds block siderophore production in bacteria and are useful as antibacterial agents.

REFERENCES:
patent: 5824657 (1998-10-01), Hill et al.
patent: WO 2006/113615 (2006-10-01), None
Ferreras et al. Nature Chemical Biology (2005), vol. 1, pp. 29-32.
Kristinsson et al. In Synthesis and Chemistry of Agrochemicals IV; ACS Symposium Series (1995), pp. 206-219.
Crofton British Medical Journal (1960), pp. 370-373.
International Search Report and Written Opinion of the International Searching Authority, PCT/US2006/46433, May 24, 2007, 8 pages.
Boshoff, “The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of Metabolism”J. Biol. Chem., 279, 40174-40184 (2004).
Burns, “Selective Reduction of Disulfides by Tris(2-carboxyethyl)phosphine”,J. Org. Chem., 56, 2648-2650 (1991).
De Voss, “The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages”,Proc. Natl. Acad. Sci., 97, 1252-1257 (2000).
Domenech, “Contribution of the Mycobacterium tuberculosis MmpL Protein Family to Virulence and Drug Resistance”,Infection and Immunity, 73, 3492-3501 (2005).
Ferreras, “Small-molecule inhibition of siderophore biosynthesis inMycobacterium tuberculosisandYersinia pestis”, Nature Chemical Biology, Vo. 1 Num. 1, 29-32 (2005).
Linne, “Reactions Catalyzed by Mature and Recombinant Nonribosomal Peptide Synthetases”,Methods Enzymol., 388, 293-315 (2004).
Liu, “A General Synthesis of 5'-Azido-5'-deoxy-2',3'-O-isopropylidene Nucleosides”,J. Org. Chem.66, 8643-8645 (2001).
Somu, “Rationally Designed Nucleoside Antibiotics that Inhibit Siderophore Biosynthesis ofMycobacterium tuberculosis”, J. Med. Chem., 49(1), 31-34 (2006).
Tibshirani, “Diagnosis of multiple cancer types by shrunken centroids of gene expression”,Proc. Natl. Acad. Sci., 99, 6567-6572 (2002).
Vannada, “Design, Synthesis, and Biological Evaluation of β-Ketosulfonamide Adenylation Inhibitors as Potential Antitubercular Agents”,Org. Lett., 8(21), 4707-4710 (2006).
Vergne, “Iron Chelators from Mycobacteria (1954-1999) and Potential Therapeutic Applications”,Nat. Prod. Rep., 17(1), 99-116 (2000).
Wayne, “Nonreplicating Persistence of Mycobacterium Tuberculosis”,Ann. Rev. Microbiol., 55, 139-163 (2001).

Affiliated with

Also associated with

Rating

Antibacterial agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibacterial agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibacterial agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2676667