Antiatherosclerotic ureas and thioureas

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514585, 514586, 514587, 514588, 514589, 514597, 514598, 564 49, 564 52, A61K 31175, C07C12719

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active

046236627

ABSTRACT:
This invention is concerned with ureas and thioureas which may be represented by the formula: ##STR1## wherein X represents at least one substituent selected from the group consisting of (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkenyl, (C.sub.1 -C.sub.4)alkynyl, phenoxy, mercapto, amino, (C.sub.1 -C.sub.4)alkylamino, di-(C.sub.1 -C.sub.4)alkylamino, halo, trihalomethyl, (C.sub.1 -C.sub.4)alkanoyl), benzoyl, (C.sub.1 -C.sub.4)alkanamido, haloacetamido, nitro, cyano, carboxy, (C.sub.1 -C.sub.4)carboalkoxy, carbamoyl, sulfamyl, methylenedioxy, phenyl, orthophenylene, tolyl, benzyl, halobenzyl, methylbenzyl; Y is selected from the group consisting of oxygen and sulfur; R.sub.1 and R.sub.2 are different and are independently selected from the group consisting of (C.sub.4 -C.sub.12)alkyl, (C.sub.4 -C.sub.12)alkenyl, (C.sub.4 -C.sub.12)alkynyl, (C.sub.4 -C.sub.12)cycloalkylalkyl, (C.sub.7 -C.sub.14)aralkyl, and (C.sub.7 -C.sub.14)aralkyl in which an aromatic ring bears at least one substituent selected from the group consisting of (C.sub.1 -C.sub.10)alkyl, (C.sub.1 -C.sub.10)alkoxy, phenoxy, benzyloxy, methylenedioxy, (C.sub.1 -C.sub.14)alkylthio, phenyl, halo, trihalomethyl, adamantyl, (C.sub.1 -C.sub.4)carboalkoxy, and nitro.

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