Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1997-12-30
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142282, 5142285, 5142352, 5142355, 5142358, 514253, 514320, 544120, 544121, 544122, 544124, 544129, 544141, 544151, 544376, 544 61, 544 90, 544 91, 544 92, A61K 31535, A61K 3154, C07D41304, C07D41314
Patent
active
057030758
ABSTRACT:
This invention relates to compounds of Formula I ##STR1## which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of Formula I are useful inhibitors of cell proliferation.
REFERENCES:
patent: 3491092 (1970-01-01), Grigat et al.
patent: 4092416 (1978-05-01), Winter et al.
Lee, K.T. "Atherosclerosis" Annals of N.Y. Academy of Science, v. 454, p. 42 (1985) * copy in parent case.
Derwent Abstract, Accession No. 79169A/44 (Japanese JA-025657) (1979).
Derwent Abstract, Accession No. 87-150605/21 (Japanese JP-259603) (1987).
Eaton, R. P., "High Density Lipoprotein--Key to Anti-Atherogenesis", J. Chron. Dis. 31:131-135 (1978).
Haust, M. D., "Reaction Patterns of Intimal Mesenchyme to Injury and Repair in Atherosclerosis", Adv. Exp. Med. Biol. 43:35-57 (1974).
Schurr, P. E., et al., "High Volume Screening Procedure for Hypobetalipoproteinemic Activity in Rats", Adv. Exp. Med. Biol. 67:215-229, Plasma Press (1975).
Day, C. E., et al., "Utility of a Selected Line (SEA) of the Japanese Quail (Coturnix Coturnix Japonica) for the Discovery of New Anti-Atherosclerosis Drugs", Lab. An. Sci. 27(5):817-821 (1977).
Mazzel, M., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco, Ed. Sci. 40:895-908 (1985).
Mazzei, M., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco. Ed. Sci. 41:611-621 (1986).
Balbi, A., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco. Ed. Sci. 37:582-596 (1982).
Ermili, A., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco. Ed. Sci. 32:375-387 (1977).
Ermili, A., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco. Ed. Sci. 32:713-724 (1977).
Balbi, A., et al., "Nitroderivati Di 2-(Dialchilammino)Cromoni", Farmaco. Ed. Sci. 38:784-793 (1983).
Balbi, A., et al., "Nitroderivati Di 2-(Dialchilammino)Cromoni", Farmaco. Ed. Sci. 41(7):548-547 (1986).
Mouysset, G., et al., "Pharmacomodulation d'adreenolytiques .alpha. en serie benzopyrqnnique", Eur. J. Med. Chem. 22(6):539-544 (1987).
Eiden, F., et al., "Uber die Reaktion von 3-Hydroxychromon mit Aminen", Arch. Pharm. (Weinheim Ger.) 308:385-388 (1975).
Ali, S. A., et al., "The Chemistry of Fungi. Part LXVII. Synthesis of J. Chem. Soc. Perkin Trans. I:173-174 (1973).
Eiden, F. and G. Rademacher, "Synthese und Reaktionen von 3-Acyl-2-methylthio-chromonen", Arch. Pharm. (Weinheim Ger.) 316:34-42 (1983).
Bantick, J. R. and J. L. Suschitzky, "Synthesis of 2-Aminochromones. Studies on the Nucleophilic Displacement of Sulphinyl and Sulphonyl Groups in the 2-Position of 5,8-Dimethoxychromone", J. Heterocyclic Chem. 18:679-684 (1981).
Mazzei, M., et al., "Synthesis and Anti-Platelet Activity of Some 2-(Dialkylamino)Chromones", Eur. J. Med. Chem. 23:237-242 (1988).
Tronchet, J. M. J., et al., "Enaminosucres et sucres halogenoacetyleniques", Helv. Chim. Acta 59:941-944 (1976).
Grigat, E., et qal., "4H-1.3-Benzoxazinon-Derivate aus aromatischen Cyansaureestern mit einer ortho-standigen carbonsaurefunktion", Chem. Ber. 97:3036-3044 (1964).
Jpn. Tokkyo Koho 79 20,504, "Oxazine and Thiazine Derivatives", CA 91:157755b, p. 644, (1979).
Jpn. Kokai 72 17,781, "Oxazine or Thiazine Derivatives", CA 77:140107e, p. 454 (1972).
Kokel, B., et al., "A New `One Pot` Preparation of Corresponding Ortho Hydroxynitriles and Phosgeniminium Salts", Tet, Letters, 25(35):3837-3840 (1984).
Palazzo, S. and L. I. Giannola, "Reazione Della 2H-1,3-Benzossazina-2-Tione-4(3H)-One Con Ammine Primarie", Atti. Acad. Sci. Lett., Parte 1. 34(2):83-87 (1976).
Brunetti, H. and C. E. Lothi, "Die Synthese von Asymmetrisch Substituierten o-Hydroxyphenyl-s-triazinen", Helv. Chim. Acta, 55:1566-1595 (1972).
Gammill Ronald B.
Judge Thomas M.
Morris Joel
Chang Ceila
Jameson William G.
Pharmacia & Upjohn Company
LandOfFree
Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-202439